In vitro experiments demonstrate the addition of vitamin B6 and zinc to azelaic acid allows azelaic acid to be used in small quantities to inhibit the synthesis of DHT in the skin.

Zinc, however, forms insoluble salts when it reacts with minoxidil/azelaic acid, rendering the active ingredients ineffective.

No credible studies relating to the absorption dynamics of topical vitamin B6 have been found.

Exhaustive research has been undertaken. Chairpersons of pharmacology departments from numerous universities have generously shared their research data. We cannot find information concerning the efficacy or safety of topical B6 as it relates to hair regrowth. in conjunction with azelaic acid. Without this vital information, it's irresponsible and irrational to add B6 to the minoxidil/azelaic acid solutions.

Therefore, azelaic acid in amounts that are effective for more than three standard deviations (>99%) of patients has been added to Xandrox formulations (a 5% concentration).

Richard Lee, M.D.

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